|
KMID : 1038620190370020082
|
|
Radiation Oncology Journal
2019 Volume.37 No. 2 p.82 ~ p.90
|
|
|
Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution
|
|
Lee Jeong-Won
Lee Jeong-Eun
Park Jun-Hee
Sohn Jin-Ho
Ahn Dong-Bin
|
|
|
Abstract
|
|
|
Purpose: To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer.
Materials and Methods: Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions. Forty-three patients received a simultaneous integrated boost (SIB) of 2.3?2.5 Gy per tumor fraction.
Results: The median follow-up duration was 29.9 months (range, 5.5 to 76.5 months). All patients achieved complete remission at a median of 50 days after the end of radiotherapy (range, 14 to 206 days). The 5-year rates for locoregional recurrence-free survival was 88.1%, and the 5-year overall survival rate was 86.2%. T2 stage was a prognostic factor for locoregional recurrence-free survival after radiotherapy (p = 0.002). SIB for the tumor did not affect disease control and survival (p = 0.191 and p = 0.387, respectively). No patients experienced acute or chronic toxicities of ≥grade 3. IMRT significantly decreased the dose administered to the carotid artery as opposed to 3D CRT (V35, p < 0.001; V50, p < 0.001).
Conclusions: Patients treated with HFX achieved acceptable locoregional disease control rates and overall survival rates compared with previous HFX studies. A fraction size of 2.25 Gy provided good disease control regardless of SIB administration.
|
|
|
KEYWORD
|
|
|
Radiotherapy, Glottis, Radiation dose hypofractionation, Intensity-modulated radiotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|